Acc2K and the MySQL ODBC Connectors worked more or less as expected on WinXP. With the advent of 64-bit Windowses, supporting Acc2K-to-ODBC started getting a bit complicated.
32-bit Acc2K requires a 32-bit MySQL Connector. Fair enough. The ODBC manager found via Control Panel ~ Administrative Tools ~ Data Sources (ODBC) in x64 Windows invokes %windir%\system32\odbcad32.exe, which is the 64-bit ODBC admin tool. 32-bit drivers must be configured with the 32-bit admin tool at %windir%\SysWOW64\odbcad32.exe. If you didn't know much about Windows you might assume system32 implies 32-bitness and SysWOW64, 64-bitness, but in fact it's the reverse - the SysWOW64 folder provides 32-bit legacy-compatibility versions of the 64-bit system components in system32.
Not knowing all this, I of course installed the 64-bit Connector v5.2.4, and the Control Panel ~ Admin Tools ~ Data Sources (ODBC) tool "saw" it, but of course Access did not. So I fell back to the 32-bit connector. I'd intended to uninstall the 64-bit connector, but rushed and ended up with both 32- and 64-bit connectors installed. Now the MySQL ODBC 5.2w driver was usable via the 32-bit ODBC Admin utility at %SystemRoot%\SysWOW64\odbcad32.exe "Create New Data Source".
So I stepped through creating a System DSN. Now in Acc2K, File ~ Get External Data ~ Link Tables ~ Files of Type... ODBC() ~ Machine Data Source presented the named System DSN as expected, but did not retrieve table names. Suspecting a privileges issue, I did GRANT ALL on [db_name] TO '[user]'@'localhost' IDENTIFIED BY '[pwd]' and FLUSH PRIVILEGES, but for some reason that didn't take; I ended up assigning privileges via SQLyog's User Manager facility. With that done, Access received a list of tables in the MySQL db represented by my ODBC System DSN. Linking one, I verified I could read data.